吴建国 - 武汉大学生命科学学院教授 免费编辑 修改义项名

1982年获武汉大学微生物学学士学位，1985年获武汉大学病毒学硕士学位，1992获美国爱达华大学生物化学博士学位，1993~1996年为美国普林斯顿大学博士后。曾先后在中科院微生物所田波院士实验室(代培研究生)、美国佐先愿模械听表许端列吸治亚大学Miller院士热实和经脱临频村意实验室(访问研究员)、美国普林斯顿大学美国微生物学院院士Newton教授实验室(研究员)、美国多瑞玛斯研究所(资深研究员)、美国塞普特药物公司(顾问)、美国国防部海军健康研究中心分子生物学实验室(主任)做科研工作。

学术兼职

1. 病毒学国家重点实验室学术委员会，副主任委员。

2. 农业微生物国家重点实验室学术委员会，副主任委员。

3. 湖北省生物工程学会，理事长。

4. 湖北省微生物学会，副理事长。

5. 中国生物工程学会，理事。

6. 中国微生物学会病毒专业委员会，理事。

2022年10月4日，武汉大学病毒学国家重点实验室发布讣告:病毒学家、武汉大学生命科学学院教授、博士生导师、原病毒学国家重点实验室主任吴建国因突发疾病，经抢救无效，于2360百科022年10月3日凌晨客斯验读吧置亚林裂1时07分在广东佛山逝世，能享年66岁。

(1)人类重要病毒致病和致癌的分子机理研究;

(2)抗病毒和抗肿瘤新药物群穿研发;

(3)呼吸道病毒的分子生物学与流行病学研究;

(4)人体细胞核受体新药物的研究和开发;

(5)致病真菌遗传基因组的结构与功能研另持究;

(6)信息传导系统在调控细胞分裂与分化中的作用机理研究;

(7)基因转录调控的分子机理研究;

(8)真菌生长与发育的机理研究等。

在重要学术刊物上发表学术论文30余篇，出版著作1部，成果鉴定1项，专利4项。

主持国家科技重大专项、国家关除他府抗科屋光切科技部973计划项目、国家自然科学基金重点项目等多项。

1.相流职易呢师消微周非Chen YN, Chen JB, Wang H, Shi JJ, Wu KL, L武额神视模iu S, Liu YL, Wu JG (2013). HCV-ind更设拿uced miR-21 超甲认自重粉复善社contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog 9(4):e1003248. (IF:9.629)

2.Xia C, Chen YC, Gong H, Zeng WB, Vu GP, Trang P, Lu SW, Wu JG, Liu FY (2013). Inhibition of hepatitis B v故处异占末均irus gene expression and replication by ribonucleas圆跳几降高秋形e P. Mol Ther 21(5):995-1003. (IF:6.284)

3.Cao YH, Zhang W, Yu Y, Zhu CL, Zh采选科吃相掌田华技提ang R, Song Y, Wang Q, Bai L, Liu YL, Wu KL, Wu JG (2013). IL-27, a cytokine, and IL-29, a type III interferon, are coordinated to regulate virus replication in a manner similar to type I interferon. J Immunol (Accepted) (IF:5.745)

4.Xu P, Huang ZX, Gao XD, Michel FJ, Hirsch G, Hogan RJ, Sa降减得量句望掌想kamoto K, Ho WZ, Wu JG, He B (2013). Infection of mice, fer岁若选画帮热rets, and rhesus macaques with a clinical mumps virus isolate. J Virol 87(14):81是抗58-8168. (IF:5.189)

5.Yu Y, Cao YH, Sun 脱ZC, Zhang W, Wu KL, Wu JG (2013). 求丝领效灯等史Hepatitis B e antigen 导则activates the suppressor of cytokine sig职压滑按还参内naling-2 t款货哥毛o antagonize type I and type III interferon and mediate 汉额源卫喜皮镇林配viral immune evasion. Eur J Immunol (In reversion) (IF:4.970)

6.Zhang Z, Vu GP, Gong H, Xia C, C很沉货聚因看响概织处hen YC, Liu FY, Wu JG, Lu SW (2013). Engineered external gui几显则衡湖想女必de sequences are highly effective in inhibiting gene 出盾福继鲁expression and replication of hepatitis B virus in cultured cells. PLoS One 8(6):e65268. (IF:略4.411)

7.Liu S, Hao Q, Wang Y, Yue X, Peng NF, Chen YN, Wu JG, Zhu Y (2012). Major vault protein: A virus-induced host factor against viral replication thro喜农杀染ugh the induction of type-I interferon. Hepatology 56(1):57-66. (IF:11.665)

8.Yue X, Wang H, Zhao F, Liu S, Wu JG, Ren W, Zhu Y (2012). H常亚素吸微epatitis B virus-induc注给存承树ed calreticulin protein is involved in interferon resistance. J Immunol 189(1):279-286. (IF:5.745)

9.Liu L, Cao ZY, Chen J, Li R, Cao YH, Zhu CL, Wu KL, Wu JG, Liu F老鸡更被山复苗助天决丰, Zhu Y (2012). Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A s附车半ignaling. J Biol Chem 287(15):11899-11910. (IF:5.328)

10.Li YX, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu WY, Xia XS, 可却星批农织歌动皇引Liu YL, Wu KL, Wu JG (2012). Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signalin前医敌待头范状g pathways金科夜双离际目出. J Virol 86(23):12531-12543. (IF:5.189)

11.Zhang Q, G计每宜单地育队发ong R, Qu J, Zhou YJ, Liu WY, Chen MZ, Liu YL, Zhu Y, Wu JG (2012). Activation of the Ras/Raf/MEK pathway facilitates HCV replication via attenuation of the INF-JAK-STAT pathway. J Virol 钢沙满普赵表雷怎职概86(3):1544-1554. (IF:5.189)

12.Fang JL, Liu L, Li YK, Wu JG, Huo XX, Zhu Y (2012). Epigenetic changes mediated by miR29 activate cyc反儿训食格头读关贵looxygenase-2 and interferon-1 production during viral infection. J Virol 86(2):胶1010-1020. (IF:5.189)

13.Xu P, L没娘指香空烈杂宜uthra PY, Li Z, Fu料沉察菜连站entes S, D'Andrea J, Wu JG, Rubin S, Rota P, He B (2012). The V protein of mumps virus pla滑包远考况手ys a critical role in pathogenesis. J Virol 86(3):画汉义盾区步立盐资该林1768-1776. 升对胶衡(IF:5.189)

14.Zeng WB, Chen YC, Bai Y, Trang P, Vu GP, Lu SW, Wu JG, Liu FY (2012). Effective inhibition of human immunodeficiency 善军北改virus 1 replication by engineered RNase P ribozyme. PLoS One 7(12):e51855. (IF:4.411)

15.Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Ci进效rcadian rhythms of feta处万银断导证副六氧终作l liver tr织食有复农比力云anscription persist in the absence of canonical circadian clock gene expression rhythms in vivo. PLoS One 7(2): e30781. (IF:4.411)

16.Li CW, Yu S, Zhong XL, Wu JG, Li XD (2012). Transcriptome comparison between fetal and adult mouse livers: Implications for circadian clock mechanisms. PLoS One 7(2): e31292. (IF:4.411)

17.Chen YN, Shen A, Rider PJ, Yu Y, Wu KL, Mu YX, Hao Q, Liu YL, Gong H, Zhu Y, Liu FY, Wu JG (2011). A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J 25(12):4511-4521. (IF:6.515)

18.Yu Y, Gong R, Mu YX, Chen YN, Zhu CL, Sun ZC, Chen MZ, Liu YL, Zhu Y, Wu JG (2011). Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, interleukin-29, interleukin-8, and cyclooxygenase-2. J Immunol 187(9):4844-4860. (IF:5.745)

19.Liu QY, Chen JW, Liu L, Zhang J, Wang DF, Ma L, He YM, Liu YL, Liu ZS, Wu JG (2011). The X protein of HBV inhibits apoptosis in hepatoma cells through enhancing MAT2A expression and reducing SAM production. J Biol Chem 286(19):17168-17180. (IF:5.328)

20.Liu QY, Liu L, Zhao YH, Zhang J, Wang DF, Chen JW, He YM, Wu JG, Zhang ZL, Liu ZS (2011). Hypoxia induces genomic DNA demethylation through the activation of HIF-1a and transcriptional up-regulation of MAT2A in hepatoma cells. Mol Cancer Ther 10(6):1113-1123. (IF:5.225)

21.Liu MY, Liu WY, Luo J, Liu YL, Zhu Y, Berman H, Wu JG (2011). Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010. PLoS One 6(9): e25287. (IF:4.411)

22.Qu J, Yang ZH, Zhang Q, Liu WY, Li YX, Ding Q, Liu F, Liu YL, Pan ZS, He B, Zhu Y, Wu JG (2011). Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by direct targeting HCV 5'-untranslated region. FEBS Lett 585(24):4002-4009. (IF:3.601)

23.Luo M, Qu X, Pan R, Zhu D, Zhang Y, Wu JG, Pan ZS (2011). The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29(14):2561-2567. (IF:3.572)

24.Xu P, Li Z, Sun DY, Lin Y, Wu JG, Rota P, He B (2011). Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenesis of mumps virus. Virology 417(1):126-136. (IF:3.305)

25.Li W, Sun W, Liu L, Yang F, Li Y, Chen Y, Fang J, Zhang W, Wu JG, Zhu Y (2010). IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J Immunol 185(9):5056-5065. (IF:5.745)

26.Li W, Yang F, Liu Y, Gong R, Liu L, Feng Y, Hu P, Sun W, Hao Q, Kang L, Wu JG, Zhu Y (2009). Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol 39(4):1019-1024. (IF:4.942)

27.Mukhtar MM, Li SF, Li W, Wan T, Mu YX, Wei W, Kang L, Rasool ST, Xiao YB, Zhu Y, Wu JG (2009). Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription. Int J Biochem Cell Biol 41(3):554-560. (IF:4.956)

28.Zhu CL, Zhang R, Liu L, Rasool ST, Mu YX, Sun W, Hao Q, Liu F, Zhu Y, Wu JG (2009). Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Clin Immunol 131(1):92-97. (IF:3.932)

29.Xia LM, Huang WJ, Wu JG, Yang YB, Zjang Q, Zhou ZZ, Zhu HF, Lei P, Shen GX, Tian GA (2009). HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB. Virology 385(2):335-342. (IF:3.305)

30.Peng GQ, Yan Y, Zhu CL, Wang SQ, Yan XH, Lu LL, Li W, Hu J, Wei W, Mu YX, Chen YN, Feng Y, Gong R, Wu KL, Zhang FM, Zhang XL, Zhu Y, Wu JG (2008). Borna disease virus P protein affects neural transmission through interacting with gamma-aminobutyric acid receptor-associated protein. J Virol 82 (24):12487-12497. (IF:5.189)

31.Wang K, Zhang Y, Li X, Chen L, Wang H, Wu JG, Zheng J, Wu D (2008). Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 283(34):23371-23375. (IF:5.328)

32.Lu LL, Wei L, Peng GQ, Mu YX, Wu KL, Kang L, Yan XH, Zhu Y, Wu JG (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371:61-70. (IF:3.305)

33.Feng Y, Wang SQ, Luo FL, Ruan Y, Kang L, Xiang XH, Peng GQ, Zhu CL, Mu YX, Zhang XL, Wu JG (2008). A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the gag and gp120 proteins of HIV-1 in immunized mice. Antivir Res 80:272-279. (IF:4.439)

34.Li W, Liu Y, Mukhtar MM, Gong R, Pan Y, Rasool ST, Gao Y, Kang L, Hao Q, Peng GQ, Chen YN, Chen X, Wu JG, Zhu Y (2008). Activation of interleukin-32 proinflammatory pathway in response to influenza A virus infection. PLoS One 3(4):e1985. (IF:4.411)

35.Liu M, Yang YB, Gu CF, Yue YP, Wu KK, Wu JG, Zhu Y (2007). Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. FASEB J 21(7):1586-1596. (IF:6.515)

36.Peng GQ, Zhang FM, Zhang Q, Wu KL, Zhu F, Wu JG (2007). Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology 366:446-452. (IF:3.305)

37.Zhang X, Wu KL, Wang D, Yue X, Song DG, Zhu Y, Wu JG (2007). Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB. Virology 365(2):324-335. (IF:3.305)

38.Li PF, Wan Q, Feng Y, Liu M, Wu JG, Chen XW, Zhang XL (2007). Engineering of N-glycosylation of hepatitis C virus envelope protein E2 enhances T cell responses for DNA immunization. Vaccine 25:1544-1551. (IF:3.572)

39.Wu KL, Mu YX, Hu J, Lu L, Zhang X, Yang YB, Li Y, Liu F, Song DG, Zhu Y, Wu JG (2007). Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antivir Res 74:142-149. (IF:4.439)

40.Mukhtar MM, Rasool ST, Song D, Zhu CL, Hao Q, Zhu Y, Wu JG (2007). Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J Gen Virol 88:3094-3099. (IF:3.568)

41.Yan XH, Hao Q, Mu YX, Timani KT, Ye LB, Zhu Y, Wu JG (2006). Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein. Int J Biochem Cell Biol 38(8):1417-1428. (IF:4.956)

42.Huang WJ, Liu ZC, Wei W, Wang GH, Wu JG, Zhu F (2006). Human endogenous retroviral pol RNA and protein detected and identified in the blood of individuals with schizophrenia. Schizophr Res 83(2-3):193-199. (IF:4.374)

43.Wei W, Huang WJ, Pan Y, Zhu F, Wu JG (2006). Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras. Cancer Lett 244(1):119-128. (IF:4.864)

44.Ecker DJ, Sampath R, Blyn LB, Eshoo MW, Ivy C, Ecker JA, Libby B, Samant V, Sannes-Lowery KA, Melton RE, Russell K, Freed N, Barrozo C, Wu JG, et al. (2005). Rapid identification and strain typing of respiratory pathogens for epidemic surveillance. Proc Natl Acad Sci USA 102(22):8012-8017. (IF:9.771)

45.Crum NF, Russell KL, Kaplan EL, Wallace MR, Wu JG, Ashtari P, Morris DJ, Hale BR (2005). Pneumonia outbreak associated with group a Streptococcus species at a military training facility. Clin Infect Dis 40(4):511-518. (IF:8.161)

46.Pan Q, Zhang XL, Wu HY, He PW, Wang F, Zhang MS, Hu JM, Xia B, Wu JG (2005). Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi. Antimicrob Agents Ch 49(10):4052-4060. (IF:4.672)

47.Metzgar D, Osuna M, Yingst S, Rakha M, Earhart K, Elyan D, Esmat H, Saad MD, Kajon A, Wu JG, Gray GC, Ryan MA, Russell KL (2005). PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. J Clin Microbiol 43(11):5743-5752. (IF:4.220)

48.Sun G, Guo M, Shen A, Mei F, Peng X, Gong R, Guo DY, Wu JG, Tien P, Xiao GF (2005). Bovine PrPC directly interacts with alphaB-crystalline. FEBS Lett 579:5419-5424. (IF:3.601)

49.Wang F, Zhang XL, Zhou Y, Ye LB, Qi ZT, Wu JG (2005). Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C. Immunobiology 210:283-293. (IF:4.114)

50.Blasiole D, Metzgar D, Daum L, Ryan M, Wu JG, Wills C, Le C, Freed NE, Hansen C, Gray G, Russell KL (2004). Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults. J Clin Microbiol 42 (4):1686-1693. (IF:4.220)

51.Wu JG, Ohta N, Zhao J, Newton A (1999). A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci USA 96:13068-13073. (IF:9.771)

52.Wu JG, Ohta N, Newton A (1998). An essential, multi-component signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci USA 95:1443-1448. (IF:9.771)

53.Wu JG, Miller BL (1997). Aspergillus asexual reproduction and sexual reproduction are differentially affected by transcriptional and translational mechanisms regulating stunted gene expression. Mol Cell Biol 17:6191-6201. (IF:6.188)

54.Wu JG, Ohta N, Benson AK, Ninfa A, Newton A (1997). Purification, characterization, and reconstitution of DNA-dependent RNA polymerases from Caulobacter crescentus. J Biol Chem 272:21558-21564. (IF:5.328)

55.Wu JG, Newton A (1997). Regulation of the Caulobacter flagellar gene hierarchy; not just for motility. Mol Microbiol 24:33-239. (IF:4.819)

56.Wu JG, Newton A (1997). The Caulobacter heat shock sigma factor gene rpoH is positively autoregulated from a sigma32-dependent promoter. J Bacteriol 179:514-521. (IF:3.726)

57.Wu JG, Newton A (1996). Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol 178:2094-2101. (IF:3.726)

58.Wu JG, Benson AK, Newton A (1995). Global regulation of a sigma54-dependent flagellar gene family in Caulobacter crescentus by the transcription activator FlbD. J Bacteriol 177:3241-3250. (IF:3.726)

59.Miller KY, Wu JG, Miller BL (1992). StuA is required for cell pattern formation in Aspergillus. Gene Dev 6:1770-1782. (IF:12.889)

60.Wu JG, Miller LK (1989). Sequence, transcription, and translation of a late gene of the Autographa californica nuclear polyhedrosis virus encoding a 34.8K polypeptide. J Gen Virol 70:2449-2459. (IF:3.368)

61.Tomalski MD, Wu JG, Miller LK (1988). The location, sequence, transcription, and translation of a baculovirus DNA polymerase gene. Virology 167:591-600. (IF:3.305)

62.Wu JG, Lu WJ, Tien P (1986). Multiplication of Velvet tobacco mottle virus in Nocotiana clevelandii protoplasts is resistant to alpha-Amanitin. J Gen Virol 67:2757-2762. (IF:3.368)

2011年:吴建国。药明康德生命化学研究二等奖。

2011年:吴建国。中国侨联特聘专家。

2011年:吴建国。湖北省创新创业人才。

2010年:吴建国，叶林柏，朱应，刘映乐，邬开朗。湖北省自然科学奖一等奖。

2010年:吴建国。湖北省十大有突出贡献中青年专家。

2010年:吴建国。湖北省人民政府编钟奖。

2010年:吴建国。武汉东湖高新区3551人才。

2009年:吴建国。湖北省新侨创业先进个人。